A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Pharmacological tools—‘chemical probes’—that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches. Probe development frequently begins with a high-throughput screen (HTS) of a chemical library. Herein, we describe the design, validation, and...

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Detalles Bibliográficos
Autores principales: Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063353/
https://www.ncbi.nlm.nih.gov/pubmed/27736936
http://dx.doi.org/10.1371/journal.pone.0164378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063353/
https://www.ncbi.nlm.nih.gov/pubmed/27736936
http://dx.doi.org/10.1371/journal.pone.0164378

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