A Natural Mutation in Helix 5 of the Ligand Binding Domain of Glucocorticoid Receptor Enhances Receptor-Ligand Interaction

The glucocorticoid receptor (GR) is a central player in the neuroendocrine stress response; it mediates feedback regulation of the hypothalamus-pituitary-adrenal (HPA) axis and physiological actions of glucocorticoids in the periphery. Despite intensive investigations of GR in the context of recepto...

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Detalles Bibliográficos
Autores principales: Reyer, Henry, Ponsuksili, Siriluck, Kanitz, Ellen, Pöhland, Ralf, Wimmers, Klaus, Murani, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063400/
https://www.ncbi.nlm.nih.gov/pubmed/27736993
http://dx.doi.org/10.1371/journal.pone.0164628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063400/
https://www.ncbi.nlm.nih.gov/pubmed/27736993
http://dx.doi.org/10.1371/journal.pone.0164628

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