Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21(WAF1/CIP1) activation

Mitomycin C (MC), a commonly used anticancer drug, induces DNA damage via DNA alkylation. Decarbamoyl mitomycin C (DMC), another mitomycin lacking the carbamate at C10, generates similar lesions as MC. Interstrand cross-links (ICLs) are believed to be the lesions primarily responsible for the cytoto...

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Detalles Bibliográficos
Autores principales: Cheng, Shu-Yuan, Seo, Jiwon, Huang, Bik Tzu, Napolitano, Tanya, Champeil, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063421/
https://www.ncbi.nlm.nih.gov/pubmed/27666201
http://dx.doi.org/10.3892/ijo.2016.3703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063421/
https://www.ncbi.nlm.nih.gov/pubmed/27666201
http://dx.doi.org/10.3892/ijo.2016.3703

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