C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

Hexanucleotide expansion in an intron of the C9orf72 gene causes amyotrophic lateral sclerosis and frontotemporal dementia. However, beyond bioinformatics predictions that suggested structural similarity to folliculin, the Birt-Hogg-Dubé syndrome tumor suppressor, little is known about the normal fu...

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Detalles Bibliográficos
Autores principales: Amick, Joseph, Roczniak-Ferguson, Agnes, Ferguson, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063613/
https://www.ncbi.nlm.nih.gov/pubmed/27559131
http://dx.doi.org/10.1091/mbc.E16-01-0003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063613/
https://www.ncbi.nlm.nih.gov/pubmed/27559131
http://dx.doi.org/10.1091/mbc.E16-01-0003

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