The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

The small GTPase Rab5 promotes recruitment of the Ccz1-Mon1 guanosine exchange complex to endosomes to activate Rab7, which facilitates endosome maturation and fusion with lysosomes. How these factors function during autophagy is incompletely understood. Here we show that autophagosomes accumulate d...

Descripción completa

Detalles Bibliográficos
Autores principales: Hegedűs, Krisztina, Takáts, Szabolcs, Boda, Attila, Jipa, András, Nagy, Péter, Varga, Kata, Kovács, Attila L., Juhász, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063620/
https://www.ncbi.nlm.nih.gov/pubmed/27559127
http://dx.doi.org/10.1091/mbc.E16-03-0205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063620/
https://www.ncbi.nlm.nih.gov/pubmed/27559127
http://dx.doi.org/10.1091/mbc.E16-03-0205

Ejemplares similares