Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

BACKGROUND: Based on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (7), with IC(50) value of 3.9 μM, was isolated from Caesalpinia sappan. Therefore, objectives of this research are design and synthesis of 7 and other chal...

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Detalles Bibliográficos
Autores principales: Bui, Trung Huu, Nguyen, Nhan Trung, Dang, Phu Hoang, Nguyen, Hai Xuan, Nguyen, Mai Thanh Thi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063830/
https://www.ncbi.nlm.nih.gov/pubmed/27795931
http://dx.doi.org/10.1186/s40064-016-3485-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063830/
https://www.ncbi.nlm.nih.gov/pubmed/27795931
http://dx.doi.org/10.1186/s40064-016-3485-6

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