Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties

In an exercise designed to reduce animal use, we analyzed the results of rat subchronic toxicity studies from 289 pharmaceutical compounds with the aim to predict the tumor outcome of carcinogenicity studies in this species. The results were obtained from the assessment reports available at the Medi...

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Detalles Bibliográficos
Autores principales: van der Laan, Jan Willem, Buitenhuis, Wenny H. W., Wagenaar, Laura, Soffers, Ans E. M. F., van Someren, Eugene P., Krul, Cyrille A. M., Woutersen, Ruud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063850/
https://www.ncbi.nlm.nih.gov/pubmed/27790617
http://dx.doi.org/10.3389/fmed.2016.00045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063850/
https://www.ncbi.nlm.nih.gov/pubmed/27790617
http://dx.doi.org/10.3389/fmed.2016.00045

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