Integration and exchange of split dCas9 domains for transcriptional controls in mammalian cells

Programmable and precise regulation of dCas9 functions in response to multiple molecular signals by using synthetic gene circuits will expand the application of the CRISPR-Cas technology. However, the application of CRISPR-Cas therapeutic circuits is still challenging due to the restrictive cargo si...

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Detalles Bibliográficos
Autores principales: Ma, Dacheng, Peng, Shuguang, Xie, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063958/
https://www.ncbi.nlm.nih.gov/pubmed/27694915
http://dx.doi.org/10.1038/ncomms13056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063958/
https://www.ncbi.nlm.nih.gov/pubmed/27694915
http://dx.doi.org/10.1038/ncomms13056

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