Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

Descripción completa

Detalles Bibliográficos
Autores principales: Doherty, Christine M., Visse, Robert, Dinakarpandian, Deendayal, Strickland, Dudley K., Nagase, Hideaki, Troeberg, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063997/
https://www.ncbi.nlm.nih.gov/pubmed/27582494
http://dx.doi.org/10.1074/jbc.M116.733261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063997/
https://www.ncbi.nlm.nih.gov/pubmed/27582494
http://dx.doi.org/10.1074/jbc.M116.733261

Ejemplares similares