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Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels of the inhibitor are regulated by the balance between its retention on the extracellular matrix and its endocytic clearance by the scavenger...

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Detalles Bibliográficos
Autores principales:	Doherty, Christine M., Visse, Robert, Dinakarpandian, Deendayal, Strickland, Dudley K., Nagase, Hideaki, Troeberg, Linda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063997/ https://www.ncbi.nlm.nih.gov/pubmed/27582494 http://dx.doi.org/10.1074/jbc.M116.733261

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