Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins

Cephalexin (1) was acylated using N-acylbenzotriazoles (3a–k′) derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%–96%). Antibacterial screening of the novel cephalosporins revealed that all targets (4a–j)...

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Detalles Bibliográficos
Autores principales: Agha, Khalid A., Abo-Dya, Nader E., Ibrahim, Tarek S., Abdel-Aal, Eatedal H., Hegazy, Wael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064239/
https://www.ncbi.nlm.nih.gov/pubmed/28117314
http://dx.doi.org/10.3390/scipharm84030484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064239/
https://www.ncbi.nlm.nih.gov/pubmed/28117314
http://dx.doi.org/10.3390/scipharm84030484

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