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S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin

Bacterial pneumonia, such as those caused by Staphylococcus aureus, is associated with an influx of inflammatory neutrophils into the lung tissue and airways. Regulation and clearance of recruited neutrophils is essential for preventing tissue damage by “friendly fire”, a responsibility of macrophag...

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Detalles Bibliográficos
Autores principales: Cohen, Taylor S., Jones-Nelson, Omari, Hotz, Meghan, Cheng, Lily, Miller, Lloyd S., Suzich, JoAnn, Stover, C. Kendall, Sellman, Bret R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064327/
https://www.ncbi.nlm.nih.gov/pubmed/27739519
http://dx.doi.org/10.1038/srep35466