Senescence Mediated by p16(INK4a) Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors

Human corneal endothelial cells (HCECs) have limited proliferative capacity due to “contact-inhibition” at G1 phase. Such contact-inhibition can be delayed from Day 21 to Day 42 by switching EGF-containing SHEM to LIF/bFGF-containing MESCM through transient activation of LIF-JAK1-STAT3 signaling tha...

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Detalles Bibliográficos
Autores principales: Lu, Wen-Juan, Tseng, Scheffer C. G., Chen, Shuangling, Tighe, Sean, Zhang, Yuan, Liu, Xin, Chen, Szu-Yu, Su, Chen-Wei, Zhu, Ying-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064359/
https://www.ncbi.nlm.nih.gov/pubmed/27739458
http://dx.doi.org/10.1038/srep35166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064359/
https://www.ncbi.nlm.nih.gov/pubmed/27739458
http://dx.doi.org/10.1038/srep35166

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