Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4

BACKGROUND: Receptor occupancy (RO) assays provide a means to measure the direct interaction of therapeutics with their cell surface targets. Free receptor assays quantify cell‐surface receptors not bound by a therapeutic while total receptor assays quantify the amount of target on the cell surface....

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Detalles Bibliográficos
Autores principales: Schwickart, Martin, Chavez, Carlos, Henderson, Simon, Vainshtein, Inna, Standifer, Nathan, DelNagro, Christopher, Mehrzai, Freshta, Schneider, Amy, Roskos, Lorin, Liang, Meina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064743/
https://www.ncbi.nlm.nih.gov/pubmed/26384735
http://dx.doi.org/10.1002/cyto.b.21327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064743/
https://www.ncbi.nlm.nih.gov/pubmed/26384735
http://dx.doi.org/10.1002/cyto.b.21327

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