Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromized mouse model

AML is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a better...

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Detalles Bibliográficos
Autores principales: Qin, Haiyan, Malek, Sami, Cowell, John K, Ren, Mingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064821/
https://www.ncbi.nlm.nih.gov/pubmed/27065320
http://dx.doi.org/10.1038/onc.2016.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064821/
https://www.ncbi.nlm.nih.gov/pubmed/27065320
http://dx.doi.org/10.1038/onc.2016.118

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