Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development

BACKGROUND: Neural tube defects (NTDs) are severe congenital malformations that arise from failure of neurulation during early embryonic development. The molecular basis underlying most human NTDs still remains largely unknown. Based on the hypothesis that folic acid prevents NTDs by stimulating met...

Descripción completa

Detalles Bibliográficos
Autores principales: Rochtus, Anne, Winand, Raf, Laenen, Griet, Vangeel, Elise, Izzi, Benedetta, Wittevrongel, Christine, Moreau, Yves, Verpoorten, Carla, Jansen, Katrien, Van Geet, Chris, Freson, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064967/
https://www.ncbi.nlm.nih.gov/pubmed/27757173
http://dx.doi.org/10.1186/s13148-016-0272-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064967/
https://www.ncbi.nlm.nih.gov/pubmed/27757173
http://dx.doi.org/10.1186/s13148-016-0272-8

Ejemplares similares