Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency

Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads to lethality ≈ 2 weeks after gene disruption....

Descripción completa

Detalles Bibliográficos
Autores principales: Ballantyne, Laurel L., Sin, Yuan Yan, Al-Dirbashi, Osama Y., Li, Xinzhi, Hurlbut, David J., Funk, Colin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065044/
https://www.ncbi.nlm.nih.gov/pubmed/27761413
http://dx.doi.org/10.1016/j.ymgmr.2016.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065044/
https://www.ncbi.nlm.nih.gov/pubmed/27761413
http://dx.doi.org/10.1016/j.ymgmr.2016.10.003

Ejemplares similares