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The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour

Phosphorylation of histone H3 at serine 10 (p-H3S10) is a marker of active gene transcription. Using cognitive models of neural plasticity, p-H3S10 was shown to be downstream of extracellular signal-regulated kinase (ERK) signalling in the hippocampus. In this study, we show that nociceptive signall...

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Detalles Bibliográficos
Autores principales: Tochiki, Keri K., Maiarú, Maria, Norris, Caspar, Hunt, Stephen P., Géranton, Sandrine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065054/
https://www.ncbi.nlm.nih.gov/pubmed/27482631
http://dx.doi.org/10.1097/j.pain.0000000000000679