Chemotherapeutic Efficacy of Phosphodiesterase Inhibitors in Chagasic Cardiomyopathy

Molecular mechanisms of Trypanosoma cruzi (Tc)-induced Chagasic cardiomyopathy (CCM) are not well understood. The NO-cGMP-PKG1α pathway maintains cardiac homeostasis and inotropy and may be disturbed due to phosphodiesterase (PDE5)-mediated cGMP catabolism in CCM. To test this, C57BL/6 mice were inf...

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Detalles Bibliográficos
Autores principales: Wen, Jian-jun, Wan, Xianxiu, Thacker, John, Garg, Nisha Jain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
PRE-CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065248/
https://www.ncbi.nlm.nih.gov/pubmed/27747306
http://dx.doi.org/10.1016/j.jacbts.2016.04.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065248/
https://www.ncbi.nlm.nih.gov/pubmed/27747306
http://dx.doi.org/10.1016/j.jacbts.2016.04.005

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