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The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain

Bone cancer pain (BCP) is one of the most difficult and intractable tasks for pain management, which is associated with spinal 'neuron-astrocytic' activation. The activation of the c-Jun N-terminal kinase (JNK)/chemokine (C-C motif) ligand (CCL2) signaling pathway has been reported to be c...

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Detalles Bibliográficos
Autores principales: Guo, Chi-Hua, Bai, Lu, Wu, Huang-Hui, Yang, Jing, Cai, Guo-Hong, Wang, Xin, Wu, Sheng-Xi, Ma, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065302/
https://www.ncbi.nlm.nih.gov/pubmed/28025994
http://dx.doi.org/10.3892/ijmm.2016.2763