Proton currents constrain structural models of voltage sensor activation

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H(+) conductance (G(AQ)). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H(+) ‘shuttle’ conductance (G(SH)) in VGCs and Ci VSP, an...

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Detalles Bibliográficos
Autores principales: Randolph, Aaron L, Mokrab, Younes, Bennett, Ashley L, Sansom, Mark SP, Ramsey, Ian Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065317/
https://www.ncbi.nlm.nih.gov/pubmed/27572256
http://dx.doi.org/10.7554/eLife.18017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065317/
https://www.ncbi.nlm.nih.gov/pubmed/27572256
http://dx.doi.org/10.7554/eLife.18017

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