53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two decades ago. However, its direct contributions to p53-dependent cellular activities remain undefined. Here, we reveal that 53BP1 stimulates geno...

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Detalles Bibliográficos
Autores principales: Cuella-Martin, Raquel, Oliveira, Catarina, Lockstone, Helen E., Snellenberg, Suzanne, Grolmusova, Natalia, Chapman, J. Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065530/
https://www.ncbi.nlm.nih.gov/pubmed/27546791
http://dx.doi.org/10.1016/j.molcel.2016.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065530/
https://www.ncbi.nlm.nih.gov/pubmed/27546791
http://dx.doi.org/10.1016/j.molcel.2016.08.002

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