Cargando…

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two decades ago. However, its direct contributions to p53-dependent cellular activities remain undefined. Here, we reveal that 53BP1 stimulates geno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cuella-Martin, Raquel, Oliveira, Catarina, Lockstone, Helen E., Snellenberg, Suzanne, Grolmusova, Natalia, Chapman, J. Ross
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065530/ https://www.ncbi.nlm.nih.gov/pubmed/27546791 http://dx.doi.org/10.1016/j.molcel.2016.08.002

Ejemplares similares

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity
por: Becker, Jordan R., et al.
Publicado: (2018)

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair
por: Bártová, Eva, et al.
Publicado: (2019)

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
por: Ghodke, Indrajeet, et al.
Publicado: (2021)

The Shieldin complex mediates 53BP1-dependent DNA repair
por: Noordermeer, Sylvie M., et al.
Publicado: (2018)

Rigor of cell fate decision by variable p53 pulses and roles of cooperative gene expression by p53
por: Murakami, Yohei, et al.
Publicado: (2012)

Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
por: Hat, Beata, et al.
Publicado: (2016)

53BP1: keep an eye on merotely
por: Tang, Mengfan, et al.
Publicado: (2017)

53BP1: a DSB escort
por: Mirman, Zachary, et al.
Publicado: (2020)

Acetylation of 53BP1 dictates the DNA double strand break repair pathway
por: Guo, Xiang, et al.
Publicado: (2018)

TPX2 joins 53BP1 to maintain DNA repair and fork stability
por: Cantor, Sharon
Publicado: (2019)

Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review)
por: Lei, Tiantian, et al.
Publicado: (2022)

At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity
por: Rizzotto, Dario, et al.
Publicado: (2021)

p53 dynamics orchestrates with binding affinity to target genes for cell fate decision
por: Wu, Mengqiu, et al.
Publicado: (2017)

Formal verification confirms the role of p53 protein in cell fate decision mechanism
por: Mahmoud, Eman Abdelaziz, et al.
Publicado: (2022)

Tying the loose ends together in DNA double strand break repair with 53BP1
por: Adams, Melissa M, et al.
Publicado: (2006)

Phase separation of 53BP1 determines liquid‐like behavior of DNA repair compartments
por: Kilic, Sinan, et al.
Publicado: (2019)

HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
por: Zhang, Zhen, et al.
Publicado: (2023)

53BP1 is required for class switch recombination
por: Ward, Irene M., et al.
Publicado: (2004)

Around and beyond 53BP1 Nuclear Bodies
por: Fernandez-Vidal, Anne, et al.
Publicado: (2017)

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
por: Minter-Dykhouse, Katherine, et al.
Publicado: (2008)

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
por: Knights, Chad D., et al.
Publicado: (2006)

CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
por: Jeffery, Daniel, et al.
Publicado: (2021)

p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision
por: Bouafia, Amine, et al.
Publicado: (2014)

DEC1 and MIC-1: New players of p53-dependent cell fate decision
por: Qian, Yingjuan, et al.
Publicado: (2012)

RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair
por: An, Liwei, et al.
Publicado: (2018)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
por: Rother, Magdalena B., et al.
Publicado: (2020)

Dominant effects of Δ40p53 on p53 function and melanoma cell fate
por: Takahashi, Rie, et al.
Publicado: (2013)

Opposing roles for 53BP1 during homologous recombination
por: Kakarougkas, Andreas, et al.
Publicado: (2013)

53BP1 contributes to regulation of autophagic clearance of mitochondria
por: Youn, Cha Kyung, et al.
Publicado: (2017)

A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities
por: Tian, Xiao-Jun, et al.
Publicado: (2012)

p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions
por: Harton, Marie D, et al.
Publicado: (2019)

Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision
por: Sun, Cheng-Yuan, et al.
Publicado: (2019)

The 53BP1 Homolog in C. elegans Influences DNA Repair and Promotes Apoptosis in Response to Ionizing Radiation
por: Ryu, Jin-Sun, et al.
Publicado: (2013)

The role of 53BP1 protein in homology-directed DNA repair: things get a bit complicated
por: Malewicz, Michal
Publicado: (2016)

PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation
por: Hwang, Jee Won, et al.
Publicado: (2020)

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT(2) Domain with γH2AX
por: Baldock, Robert A., et al.
Publicado: (2015)

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways
por: Rappold, Irene, et al.
Publicado: (2001)

Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay
por: Fontaine, Maelle, et al.
Publicado: (2023)

p53 integrates host defense and cell fate during bacterial pneumonia
por: Madenspacher, Jennifer H., et al.
Publicado: (2013)

Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
por: Farkas, Marina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_odfffre5g3r8iqe8rh0lnov1so