Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer

Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα, and DGKζ, specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell receptor (TCR). Deletion of either isoform in...

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Detalles Bibliográficos
Autores principales: Riese, Matthew J., Moon, Edmund K., Johnson, Bryon D., Albelda, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065962/
https://www.ncbi.nlm.nih.gov/pubmed/27800476
http://dx.doi.org/10.3389/fcell.2016.00108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065962/
https://www.ncbi.nlm.nih.gov/pubmed/27800476
http://dx.doi.org/10.3389/fcell.2016.00108

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