Discovery of Potential Inhibitors of Aldosterone Synthase from Chinese Herbs Using Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Studies

Aldosterone synthase (CYP11B2) is a key enzyme for the biosynthesis of aldosterone, which plays a significant role for the regulation of blood pressure. Excess aldosterone can cause the dysregulation of the renin-angiotensin-aldosterone system (RAAS) and lead to hypertension. Therefore, research and...

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Detalles Bibliográficos
Autores principales: Luo, Ganggang, Lu, Fang, Qiao, Liansheng, Chen, Xi, Li, Gongyu, Zhang, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065998/
https://www.ncbi.nlm.nih.gov/pubmed/27781210
http://dx.doi.org/10.1155/2016/4182595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065998/
https://www.ncbi.nlm.nih.gov/pubmed/27781210
http://dx.doi.org/10.1155/2016/4182595

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