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Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones

Fused cyclobutanes are found in a range of natural products and formation of these motifs in a straightforward and easy manner represents an interesting synthetic challenge. To this end we investigated an intramolecular variant of the thermal enamine [2 + 2] cyclisation, developing a diastereoselect...

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Detalles Bibliográficos
Autores principales: Throup, Adam, Patterson, Laurence H., Sheldrake, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066561/
https://www.ncbi.nlm.nih.gov/pubmed/27722445
http://dx.doi.org/10.1039/c6ob01661h