Evidence, eminence and extrapolation

A full independent drug development programme to demonstrate efficacy may not be ethical and/or feasible in small populations such as paediatric populations or orphan indications. Different levels of extrapolation from a larger population to smaller target populations are widely used for supporting...

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Detalles Bibliográficos
Autores principales: Hlavin, Gerald, Koenig, Franz, Male, Christoph, Posch, Martin, Bauer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066662/
https://www.ncbi.nlm.nih.gov/pubmed/26753552
http://dx.doi.org/10.1002/sim.6865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066662/
https://www.ncbi.nlm.nih.gov/pubmed/26753552
http://dx.doi.org/10.1002/sim.6865

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