Identification of p38 MAPK and JNK as new targets for correction of Wilson disease‐causing ATP7B mutants

Wilson disease (WD) is an autosomal recessive disorder that is caused by the toxic accumulation of copper (Cu) in the liver. The ATP7B gene, which is mutated in WD, encodes a multitransmembrane domain adenosine triphosphatase that traffics from the trans‐Golgi network to the canalicular area of hepa...

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Detalles Bibliográficos
Autores principales: Chesi, Giancarlo, Hegde, Ramanath N., Iacobacci, Simona, Concilli, Mafalda, Parashuraman, Seetharaman, Festa, Beatrice Paola, Polishchuk, Elena V., Di Tullio, Giuseppe, Carissimo, Annamaria, Montefusco, Sandro, Canetti, Diana, Monti, Maria, Amoresano, Angela, Pucci, Piero, van de Sluis, Bart, Lutsenko, Svetlana, Luini, Alberto, Polishchuk, Roman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Steatohepatitis/Metabolic Liver Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066671/
https://www.ncbi.nlm.nih.gov/pubmed/26660341
http://dx.doi.org/10.1002/hep.28398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066671/
https://www.ncbi.nlm.nih.gov/pubmed/26660341
http://dx.doi.org/10.1002/hep.28398

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