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Mitigating the Effects of Nonadherence in Clinical Trials

Accounting for subject nonadherence and eliminating inappropriate subjects in clinical trials are critical elements of a successful study. Nonadherence can increase variance, lower study power, and reduce the magnitude of treatment effects. Inappropriate subjects (including those who do not have the...

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Detalles Bibliográficos
Autores principales: Shiovitz, Thomas M., Bain, Earle E., McCann, David J., Skolnick, Phil, Laughren, Thomas, Hanina, Adam, Burch, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066799/
https://www.ncbi.nlm.nih.gov/pubmed/26634893
http://dx.doi.org/10.1002/jcph.689