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Intracellular redox-responsive nanocarrier for plasmid delivery: in vitro characterization and in vivo studies in mice
Although some modifications of polyethyleneimine (PEI) properties have been explored to balance the transfection efficiency and cytotoxicity, its successful plasmid delivery in vitro and in vivo to realize its true therapeutic potentials remains a major challenge, mainly due to intracellular traffic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066853/ https://www.ncbi.nlm.nih.gov/pubmed/27785025 http://dx.doi.org/10.2147/IJN.S94995 |