Oxazin-5-Ones as a Novel Class of Penicillin Binding Protein Inhibitors: Design, Synthesis and Structure Activity Relationship

Penicillin binding proteins (PBPs) are normal constituents of bacterial which are absent in mammalian cells. The theoretical binding modes of known oxazin-5-ones toward the protein were used as a guide to synthesis new inhibitors. Structural studies of protein-ligand complexes revealed that conforma...

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Detalles Bibliográficos
Autores principales: Onoabedje, Efeturi Abraham, Ibezim, Akachukwu, Okafor, Sunday Nwankwor, Onoabedje, Ufuoma Shalom, Okoro, Uchechukwu Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066960/
https://www.ncbi.nlm.nih.gov/pubmed/27749913
http://dx.doi.org/10.1371/journal.pone.0163467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066960/
https://www.ncbi.nlm.nih.gov/pubmed/27749913
http://dx.doi.org/10.1371/journal.pone.0163467

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