Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle

Age-related skeletal muscle dysfunction is the underlying cause of morbidity that affects up to half the population aged 80 and over. Considerable evidence indicates that oxidative damage and mitochondrial dysfunction contribute to the sarcopenic phenotype that occurs with aging. To examine this, we...

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Detalles Bibliográficos
Autores principales: Sakellariou, Giorgos K., Pearson, Timothy, Lightfoot, Adam P., Nye, Gareth A., Wells, Nicola, Giakoumaki, Ifigeneia I., Griffiths, Richard D., McArdle, Anne, Jackson, Malcolm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067250/
https://www.ncbi.nlm.nih.gov/pubmed/27550965
http://dx.doi.org/10.1096/fj.201600450R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067250/
https://www.ncbi.nlm.nih.gov/pubmed/27550965
http://dx.doi.org/10.1096/fj.201600450R

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