ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain Barrier In Vitro

Disruption of blood-brain barrier (BBB) follows brain trauma or central nervous system (CNS) stress. However, the mechanisms leading to this process or the underlying neural plasticity are not clearly known. We hypothesized that ATP/P2X7R signaling regulates the integrity of BBB. Activation of P2X7...

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Detalles Bibliográficos
Autores principales: Yang, Fuxing, Zhao, Kai, Zhang, Xiufeng, Zhang, Jun, Xu, Bainan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067334/
https://www.ncbi.nlm.nih.gov/pubmed/27795859
http://dx.doi.org/10.1155/2016/8928530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067334/
https://www.ncbi.nlm.nih.gov/pubmed/27795859
http://dx.doi.org/10.1155/2016/8928530

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