Cargando…

Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes

Protein interactions play significant roles in complex diseases. We analyzed peripheral blood mononuclear cells (PBMC) transcriptome using a multi-method strategy. We constructed a tissue-specific interactome (T2Di) and identified 420 molecular signatures associated with T2D-related comorbidity and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing-Woei, Lee, Heung-Man, Wang, Ying, Tong, Amy Hin-Yan, Yip, Kevin Y., Tsui, Stephen Kwok-Wing, Lok, Si, Ozaki, Risa, Luk, Andrea O, Kong, Alice P. S., So, Wing-Yee, Ma, Ronald C. W., Chan, Juliana C. N., Chan, Ting-Fung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067504/ https://www.ncbi.nlm.nih.gov/pubmed/27752041 http://dx.doi.org/10.1038/srep35228

Ejemplares similares

Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
por: Lou, Shaoke, et al.
Publicado: (2014)

Discovering Loci for Breeding Prospective and Phenology in Wheat Mediterranean Landraces by Environmental and eigenGWAS
por: Yannam, Venkata Rami Reddy, et al.
Publicado: (2023)

Validation of Methods to Control for Immortal Time Bias in a Pharmacoepidemiologic Analysis of Renin–Angiotensin System Inhibitors in Type 2 Diabetes
por: Yang, Xilin, et al.
Publicado: (2014)

Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes
por: Kong, Alice PS, et al.
Publicado: (2014)

The Contribution of GWAS Loci in Familial Dyslipidemias
por: Ripatti, Pietari, et al.
Publicado: (2016)

Distribution, Persistence and Interchange of Epstein-Barr Virus Strains among PBMC, Plasma and Saliva of Primary Infection Subjects
por: Kwok, Hin, et al.
Publicado: (2015)

Mutations Enabling Displacement of Tryptophan by 4-Fluorotryptophan as a Canonical Amino Acid of the Genetic Code
por: Yu, Allen Chi-Shing, et al.
Publicado: (2014)

Quantifying Missing Heritability at Known GWAS Loci
por: Gusev, Alexander, et al.
Publicado: (2013)

GWAS reveals loci associated with velopharyngeal dysfunction
por: Chernus, Jonathan, et al.
Publicado: (2018)

Functional screens refine height GWAS loci
por: Ackert-Bicknell, Cheryl L.
Publicado: (2023)

Hypoglycaemia, chronic kidney disease and death in type 2 diabetes: the Hong Kong diabetes registry
por: Kong, Alice PS, et al.
Publicado: (2014)

Depressive Symptoms, Co-Morbidities, and Glycemic Control in Hong Kong Chinese Elderly Patients With Type 2 Diabetes Mellitus
por: Fung, Annie C. H., et al.
Publicado: (2018)

GWAS identifies four novel eosinophilic esophagitis loci
por: Sleiman, Patrick MA, et al.
Publicado: (2014)

Using Gene Expression to Annotate Cardiovascular GWAS Loci
por: Heinig, Matthias
Publicado: (2018)

Meta-GWAS for quantitative trait loci identification in soybean
por: Shook, Johnathon M, et al.
Publicado: (2021)

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
por: Barbeira, Alvaro N., et al.
Publicado: (2021)

T172. EVIDENCE OF ASSOCIATION OF THE DISC1 INTERACTOME GENE SET WITH SCHIZOPHRENIA FROM GWAS
Publicado: (2020)

The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function
por: Chan, Chak-Ming, et al.
Publicado: (2009)

The Clinical Utility of SUDOSCAN in Chronic Kidney Disease in Chinese Patients with Type 2 Diabetes
por: Luk, Andrea O. Y., et al.
Publicado: (2015)

Identifying loci with breeding potential across temperate and tropical adaptation via EigenGWAS and EnvGWAS
por: Li, Jing, et al.
Publicado: (2019)

Tc-99m sulfur colloid SPECT-CT and assessment of functional liver reserve after Y90 radioembolization: A case report
por: Chan, YeeMei, et al.
Publicado: (2019)

Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
por: Zepeda-Batista, José Luis, et al.
Publicado: (2021)

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits
por: Chun, Sung, et al.
Publicado: (2022)

networkGWAS: a network-based approach to discover genetic associations
por: Muzio, Giulia, et al.
Publicado: (2023)

Detection of splicing events and multiread locations from RNA-seq data based on a geometric-tail (GT) distribution of intron length
por: Lou, Shao-Ke, et al.
Publicado: (2011)

GWAS reveal novel IgA nephropathy risk loci
por: Foo, Jia Nee, et al.
Publicado: (2015)

Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population
por: Aslam, Muhammad Muaaz, et al.
Publicado: (2020)

The Role of Rare Coding Variants in Parkinson's Disease GWAS Loci
por: Germer, Elisabeth Luisa, et al.
Publicado: (2019)

ViralFusionSeq: accurately discover viral integration events and reconstruct fusion transcripts at single-base resolution
por: Li, Jing-Woei, et al.
Publicado: (2013)

Low HDL Cholesterol, Metformin Use, and Cancer Risk in Type 2 Diabetes: The Hong Kong Diabetes Registry
por: Yang, Xilin, et al.
Publicado: (2011)

TWAS results are complementary to and less affected by linkage disequilibrium than GWAS
por: Li, Delin, et al.
Publicado: (2021)

Network biology discovers pathogen contact points in host protein-protein interactomes
por: Ahmed, Hadia, et al.
Publicado: (2018)

Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
por: Maiorino, Enrico, et al.
Publicado: (2020)

Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case–control cohort analysis
por: Leung, Ross KK, et al.
Publicado: (2013)

Effects of gut microbiome and environment on the development of eczema in Chinese infants
por: Chan, Carmen Wing Han, et al.
Publicado: (2020)

GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease
por: Aouizerat, Bradley E, et al.
Publicado: (2011)

Validation of the traditional Chinese version of the diabetes eating problem survey-revised and study of the prevalence of disordered eating patterns in Chinese patients with type 1 DM
por: Lok, Chi Wing, et al.
Publicado: (2023)

Local and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review
por: Chan, Wing-Lok, et al.
Publicado: (2020)

ABMapper: a suffix array-based tool for multi-location searching and splice-junction mapping
por: Lou, Shao-Ke, et al.
Publicado: (2011)

Connecting SNPs in Diabetes: A Spatial Analysis of Meta-GWAS Loci
por: Schierding, William, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g21kv83j2dab6pdfsn5ta6p1ti