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DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos

DNA damage independent of caspase activation accompanies programmed cell death in different vertebrate embryonic organs. We analyzed the significance of DNA damage during the regression of the interdigital tissue, which sculpts the digits in the embryonic limb. Interdigit remodeling involves oxidati...

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Detalles Bibliográficos
Autores principales: Montero, Juan A., Sanchez-Fernandez, Cristina, Lorda-Diez, Carlos I., Garcia-Porrero, Juan A., Hurle, Juan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067507/
https://www.ncbi.nlm.nih.gov/pubmed/27752097
http://dx.doi.org/10.1038/srep35478