Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis

We investigated major determinants of the intracellular concentrations of methotrexate polyglutamates (MTXPGs) in patients with rheumatoid arthritis (RA). In 271 RA patients on stable oral low dose weekly pulse MTX therapy, the concentrations of MTXPGs in red blood cells (RBCs) were measured by liqu...

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Detalles Bibliográficos
Autores principales: Yamamoto, Tatsuhiro, Shikano, Kotaro, Nanki, Toshihiro, Kawai, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067511/
https://www.ncbi.nlm.nih.gov/pubmed/27752107
http://dx.doi.org/10.1038/srep35615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067511/
https://www.ncbi.nlm.nih.gov/pubmed/27752107
http://dx.doi.org/10.1038/srep35615

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