Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs (tRNAs) at the wobble uridine 34 (U34) base are highly conserved and contribute to translation fidelity. Here, we show that...

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Detalles Bibliográficos
Autores principales: Delaunay, Sylvain, Rapino, Francesca, Tharun, Lars, Zhou, Zhaoli, Heukamp, Lukas, Termathe, Martin, Shostak, Kateryna, Klevernic, Iva, Florin, Alexandra, Desmecht, Hadrien, Desmet, Christophe J., Nguyen, Laurent, Leidel, Sebastian A., Willis, Anne E., Büttner, Reinhard, Chariot, Alain, Close, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068235/
https://www.ncbi.nlm.nih.gov/pubmed/27811057
http://dx.doi.org/10.1084/jem.20160397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068235/
https://www.ncbi.nlm.nih.gov/pubmed/27811057
http://dx.doi.org/10.1084/jem.20160397

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