Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

Adoptive T cell therapy (ATT) can achieve regression of large tumors in mice and humans; however, tumors frequently recur. High target peptide-major histocompatibility complex-I (pMHC) affinity and T cell receptor (TCR)-pMHC affinity are thought to be critical to preventing relapse. Here, we show th...

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Detalles Bibliográficos
Autores principales: Textor, Ana, Schmidt, Karin, Kloetzel, Peter-M., Weißbrich, Bianca, Perez, Cynthia, Charo, Jehad, Anders, Kathleen, Sidney, John, Sette, Alessandro, Schumacher, Ton N.M., Keller, Christin, Busch, Dirk H., Seifert, Ulrike, Blankenstein, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068242/
https://www.ncbi.nlm.nih.gov/pubmed/27697836
http://dx.doi.org/10.1084/jem.20160636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068242/
https://www.ncbi.nlm.nih.gov/pubmed/27697836
http://dx.doi.org/10.1084/jem.20160636

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