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Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining

For more than half a century, genotoxic agents have been used to induce mutations in the genome of model organisms to establish genotype-phenotype relationships. While inaccurate replication across damaged bases can explain the formation of single nucleotide variants, it remained unknown how DNA dam...

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Detalles Bibliográficos
Autores principales:	van Schendel, Robin, van Heteren, Jane, Welten, Richard, Tijsterman, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068794/ https://www.ncbi.nlm.nih.gov/pubmed/27755535 http://dx.doi.org/10.1371/journal.pgen.1006368

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