A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells

The CKS1B gene located on chromosome 1q21 is frequently amplified in breast, lung, and liver cancers. CKS1B codes for a conserved regulatory subunit of cyclin–CDK complexes that function at multiple stages of cell cycle progression. We used a high throughput screening protocol to mimic cancer-relate...

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Detalles Bibliográficos
Autores principales: Reid, Robert J. D., Du, Xing, Sunjevaric, Ivana, Rayannavar, Vinayak, Dittmar, John, Bryant, Eric, Maurer, Matthew, Rothstein, Rodney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2016
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068864/
https://www.ncbi.nlm.nih.gov/pubmed/27558135
http://dx.doi.org/10.1534/genetics.116.190231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068864/
https://www.ncbi.nlm.nih.gov/pubmed/27558135
http://dx.doi.org/10.1534/genetics.116.190231

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