WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma

High-level amplification of the protein phosphatase PPM1D (WIP1) is present in a subset of medulloblastomas (MBs) that have an expression profile consistent with active Sonic Hedgehog (SHH) signaling. We found that WIP1 overexpression increased expression of Shh target genes and cell proliferation i...

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Detalles Bibliográficos
Autores principales: Wen, Jing, Lee, Juhyun, Malhotra, Anshu, Nahta, Rita, Arnold, Amanda R., Buss, Meghan C., Brown, Briana D., Maier, Caroline, Kenney, Anna M., Remke, Marc, Ramaswamy, Vijay, Taylor, Michael D., Castellino, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069081/
https://www.ncbi.nlm.nih.gov/pubmed/27086929
http://dx.doi.org/10.1038/onc.2016.96

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069081/
https://www.ncbi.nlm.nih.gov/pubmed/27086929
http://dx.doi.org/10.1038/onc.2016.96

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