Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding

The heterodimeric receptor tyrosine kinase complex formed by HER2 and HER3 can act as an oncogenic driver and is also responsible for rescuing a large number of cancers from a diverse set of targeted therapies. Current inhibitors of these proteins, particularly HER2, have dramatically improved patie...

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Detalles Bibliográficos
Autores principales: Novotny, Chris J., Pollari, Sirkku, Park, Jin H., Lemmon, Mark A., Shen, Weijun, Shokat, Kevan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069157/
https://www.ncbi.nlm.nih.gov/pubmed/27595329
http://dx.doi.org/10.1038/nchembio.2171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069157/
https://www.ncbi.nlm.nih.gov/pubmed/27595329
http://dx.doi.org/10.1038/nchembio.2171

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