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Carbon extension in peptidylnucleoside biosynthesis by radical-SAM enzymes

Nikkomycins and polyoxins are antifungal peptidylnucleoside (PN) antibiotics active against human and plant pathogens. Here, we report that during PN biosynthesis in Streptomyces cacaoi and Streptomyces tendae, the C5′-extension of the nucleoside essential for downstream structural diversification i...

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Detalles Bibliográficos
Autores principales: Lilla, Edward A., Yokoyama, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069167/
https://www.ncbi.nlm.nih.gov/pubmed/27642865
http://dx.doi.org/10.1038/nchembio.2187