TUT‐DIS3L2 is a mammalian surveillance pathway for aberrant structured non‐coding RNAs

Uridylation of various cellular RNA species at the 3′ end has been generally linked to RNA degradation. In mammals, uridylated pre‐let‐7 miRNAs and mRNAs are targeted by the 3′ to 5′ exoribonuclease DIS3L2. Mutations in DIS3L2 have been associated with Perlman syndrome and with Wilms tumor susceptib...

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Detalles Bibliográficos
Autores principales: Ustianenko, Dmytro, Pasulka, Josef, Feketova, Zuzana, Bednarik, Lukas, Zigackova, Dagmar, Fortova, Andrea, Zavolan, Mihaela, Vanacova, Stepanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069555/
https://www.ncbi.nlm.nih.gov/pubmed/27647875
http://dx.doi.org/10.15252/embj.201694857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069555/
https://www.ncbi.nlm.nih.gov/pubmed/27647875
http://dx.doi.org/10.15252/embj.201694857

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