Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid

The aldehyde dehydrogenase family 1 member A3 (ALDH1A3) catalyzes the oxidation of retinal to the pleiotropic factor retinoic acid using NAD(+). The level of ALDHs enzymatic activity has been used as a cancer stem cell marker and seems to correlate with tumour aggressiveness. Elevated ALDH1A3 expres...

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Detalles Bibliográficos
Autores principales: Moretti, Andrea, Li, Jianfeng, Donini, Stefano, Sobol, Robert W., Rizzi, Menico, Garavaglia, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069622/
https://www.ncbi.nlm.nih.gov/pubmed/27759097
http://dx.doi.org/10.1038/srep35710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069622/
https://www.ncbi.nlm.nih.gov/pubmed/27759097
http://dx.doi.org/10.1038/srep35710

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