Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Drug-induced cholestasis (DIC) is poorly understood and its preclinical prediction is mainly limited to assessing the compound’s potential to inhibit the bile salt export pump (BSEP). Here, we evaluated two 3D spheroid models, one from primary human hepatocytes (PHH) and one from HepaRG cells, for t...

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Detalles Bibliográficos
Autores principales: Hendriks, Delilah F. G., Fredriksson Puigvert, Lisa, Messner, Simon, Mortiz, Wolfgang, Ingelman-Sundberg, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069690/
https://www.ncbi.nlm.nih.gov/pubmed/27759057
http://dx.doi.org/10.1038/srep35434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069690/
https://www.ncbi.nlm.nih.gov/pubmed/27759057
http://dx.doi.org/10.1038/srep35434

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