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A Randomized Phase 1 Dose Escalation Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Trabodenoson in Healthy Adult Volunteers

Purpose: To investigate the safety, tolerability, and pharmacokinetics of trabodenoson, a highly selective adenosine mimetic targeting the adenosine A(1) receptor. Methods: In Part 1, 60 healthy adult volunteers were randomized to 14 days of twice-daily topical monocular application of placebo or tr...

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Detalles Bibliográficos
Autores principales:	Laties, Alan, Rich, Cadmus C., Stoltz, Randall, Humbert, Vernon, Brickman, Chaim, McVicar, William, Baumgartner, Rudolf A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069726/ https://www.ncbi.nlm.nih.gov/pubmed/27046445 http://dx.doi.org/10.1089/jop.2015.0147

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