Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1

BACKGROUND: A handful of studies have exploited antitumor potential of esculetin, a dihydroxy coumarine derivative; the targets to which it binds and the possible downstream mechanism for its cytotoxicity in cancer cells remain to be elucidated. Using pancreatic cancer cell lines as a model system,...

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Detalles Bibliográficos
Autores principales: Arora, Rashi, Sawney, Sharad, Saini, Vikas, Steffi, Chris, Tiwari, Manisha, Saluja, Daman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069780/
https://www.ncbi.nlm.nih.gov/pubmed/27756327
http://dx.doi.org/10.1186/s12943-016-0550-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069780/
https://www.ncbi.nlm.nih.gov/pubmed/27756327
http://dx.doi.org/10.1186/s12943-016-0550-2

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