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Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
BACKGROUND: A handful of studies have exploited antitumor potential of esculetin, a dihydroxy coumarine derivative; the targets to which it binds and the possible downstream mechanism for its cytotoxicity in cancer cells remain to be elucidated. Using pancreatic cancer cell lines as a model system,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069780/ https://www.ncbi.nlm.nih.gov/pubmed/27756327 http://dx.doi.org/10.1186/s12943-016-0550-2 |