Cargando…

Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide and is associated with substantial mortality. Because HCCs have strong resistance to conventional chemotherapeutic agents, novel therapeutic strategies are needed to improve survival in HCC patients. MET...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Jae-Woo, Song, Yeonhwa, Kim, Kang Mo, Kim, Jin-Sun, Choi, Eun Kyung, Kim, Joon, Seo, Haengran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069815/ https://www.ncbi.nlm.nih.gov/pubmed/27756242 http://dx.doi.org/10.1186/s12885-016-2816-x

Ejemplares similares

TGF-β–independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCC
por: Song, Yeonhwa, et al.
Publicado: (2017)

Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids
por: Song, Yeonhwa, et al.
Publicado: (2016)

Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells
por: Song, Yeonhwa, et al.
Publicado: (2017)

Oxytetracycline have the therapeutic efficiency in CD133(+) HCC population through suppression CD133 expression by decreasing of protein stability of CD133
por: Song, Yeonhwa, et al.
Publicado: (2018)

Effects of glucose concentration in the medium on rat hepatocyte culture
por: Na, Gun Hyung, et al.
Publicado: (2014)

Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC)
por: Huang, Jingquan, et al.
Publicado: (2023)

Strategies for HCC target discovery
por: Molina-Sánchez, Pedro, et al.
Publicado: (2017)

Hepatocellular carcinoma: HCC
por: Blum, Hubert E.
Publicado: (2011)

SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells
por: Riccioni, Veronica, et al.
Publicado: (2022)

Human Hepatocellular Carcinoma (HCC)
por: Buonaguro, Luigi
Publicado: (2020)

Immune System and Hepatocellular Carcinoma (HCC): New Insights into HCC Progression
por: Kotsari, Maria, et al.
Publicado: (2023)

Overexpressed Proteins in HCC Cell-Derived Exosomes, CCT8, and Cofilin-1 Are Potential Biomarkers for Patients with HCC
por: Cho, Hyo Jung, et al.
Publicado: (2021)

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma
por: Song, Yeonhwa, et al.
Publicado: (2018)

3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes
por: Kim, Yeonhee, et al.
Publicado: (2010)

Effects of Prostaglandins on Ethanol Damage in Primary Cultured Rat Hepatocytes
por: Yang, Jin Mo, et al.
Publicado: (1998)

MRI in detection of hepatocellular carcinoma (HCC)
por: Digumarthy, Subba R, et al.
Publicado: (2005)

Emerging Therapies for Hepatocellular Carcinoma (HCC)
por: Chakraborty, Eesha, et al.
Publicado: (2022)

Advances in Immunotherapy for Hepatocellular Carcinoma (HCC)
por: Bicer, Fuat, et al.
Publicado: (2023)

Pharmacological Unmasking Microarray Approach-Based Discovery of Novel DNA Methylation Markers for Hepatocellular Carcinoma
por: Jung, Namhee, et al.
Publicado: (2012)

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
por: Ge, Chenxu, et al.
Publicado: (2022)

Machine-Learning-Based Clinical Biomarker Using Cell-Free DNA for Hepatocellular Carcinoma (HCC)
por: Lee, Taehee, et al.
Publicado: (2022)

The Value of Survivin Gene and Proliferation of Hepatocytes in Screening for Hepatocellular Carcinoma
por: Jia, Ke Dong, et al.
Publicado: (2009)

Increased Levels of Phosphorylated ERK Induce CTGF Expression in Autophagy-Deficient Mouse Hepatocytes
por: Seo, Hye-Young, et al.
Publicado: (2022)

Inhibitors of Na(+)/K(+) ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma
por: Song, Yeonhwa, et al.
Publicado: (2020)

Structure-Based Virtual Screening towards the Discovery of Novel ULK1 Inhibitors with Anti-HCC Activities
por: Gao, Yang, et al.
Publicado: (2022)

Drug Discovery Using Evolutionary Similarities in Chemical Binding to Inhibit Patient-Derived Hepatocellular Carcinoma
por: Lim, Jin Hong, et al.
Publicado: (2022)

Improved Outcomes Following Hepatocellular Carcinoma (HCC) Diagnosis in Patients Screened for HCC in a Large Academic Liver Center versus Patients Identified in the Community
por: Okoronkwo, Nneoma, et al.
Publicado: (2017)

Development of a nomogram for screening of hepatitis B virus-associated hepatocellular carcinoma
por: Chung, Jung Wha, et al.
Publicado: (2017)

Feasibility of 10-Minute Delayed Hepatocyte Phase Imaging Using a 30° Flip Angle in Gd-EOB-DTPA-Enhanced Liver MRI for the Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis or Cirrhosis
por: Jeon, Inhwan, et al.
Publicado: (2016)

Anti-Cancer Effects of YAP Inhibitor (CA3) in Combination with Sorafenib against Hepatocellular Carcinoma (HCC) in Patient-Derived Multicellular Tumor Spheroid Models (MCTS)
por: Han, Sojung, et al.
Publicado: (2022)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
por: Kim, Sanghwa, et al.
Publicado: (2021)

Molecular Signature and Immune Landscape of HCV-Associated Hepatocellular Carcinoma (HCC): Differences and Similarities with HBV-HCC
por: De Battista, Davide, et al.
Publicado: (2021)

Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes
por: Song, Jinsoo, et al.
Publicado: (2022)

Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC)
por: Jeon, Jeong Yong, et al.
Publicado: (2018)

Molecular and Metabolic Phenotyping of Hepatocellular Carcinoma for Biomarker Discovery: A Meta-Analysis
por: Anh, Nguyen Hoang, et al.
Publicado: (2023)

Type conversion of secretomes in a 3D TAM2 and HCC cell co-culture system and functional importance of CXCL2 in HCC
por: Lu, Yu, et al.
Publicado: (2016)

Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)
por: Pazgan-Simon, Monika, et al.
Publicado: (2020)

NF-Y Overexpression in Liver Hepatocellular Carcinoma (HCC)
por: Bezzecchi, Eugenia, et al.
Publicado: (2020)

A Curious Case of Vanishing Hepatocellular Carcinoma (HCC)
por: Kwei-Nsoro, Robert, et al.
Publicado: (2023)

SERPINA3 is a key modulator of HNRNP-K transcriptional activity against oxidative stress in HCC
por: Ko, Eunkyong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qvqqbgir3kdl24v4edm4m8n06o